@import url('https://fonts.googleapis.com/css2?family=DM+Sans:wght@400;500;600;700&family=Manrope:wght@400;500;600;700;800&display=swap');

:root{--ink:#222222;--muted:#666666;--blue:#2E6FBA;--line:#DEDEDE;--light:#F5F5F5;--bg:#FFFFFF;font-family:'DM Sans',system-ui,sans-serif;color:var(--ink);background:var(--bg);font-synthesis:none}*{box-sizing:border-box}body{margin:0}button,input,select{font:inherit}button,a,input,select,summary{-webkit-tap-highlight-color:transparent}button,a{touch-action:manipulation}button{cursor:pointer}a{color:var(--blue);text-decoration:none}a:hover{text-decoration:underline}button:focus-visible,a:focus-visible,input:focus-visible,select:focus-visible,summary:focus-visible{outline:3px solid #2E6FBA;outline-offset:3px}button{color:var(--ink)}.header{height:76px;display:flex;align-items:center;gap:48px;padding:0 38px;border-bottom:1px solid var(--line);background:#fff}.brand{display:flex;align-items:center;gap:11px;color:var(--ink);text-decoration:none!important}.brand svg{width:36px;height:36px;fill:none;stroke:var(--blue);stroke-width:2.8;stroke-linecap:round;stroke-linejoin:round}.brand strong{font-family:Manrope,sans-serif;font-size:23px;letter-spacing:-1px}.brand strong span{font-weight:400;margin-left:7px;color:var(--muted)}nav{display:flex;gap:30px;height:100%;align-items:center}nav a,nav button{font-size:13px;font-weight:600;color:var(--muted);background:none;border:0;padding:0;white-space:nowrap}nav .active{color:var(--blue);height:100%;display:flex;align-items:center;border-bottom:2px solid var(--blue)}.release{margin-left:auto;display:flex;align-items:center;gap:7px;color:var(--muted);font-size:11px}.release i{width:6px;height:6px;border-radius:50%;background:#2E6FBA}main{max-width:1560px;margin:auto;padding:32px 38px 0}.intro{display:flex;align-items:center;justify-content:space-between;margin-bottom:30px}.eyebrow{font-size:10px;letter-spacing:1.8px;font-weight:700;color:var(--muted);margin:0 0 9px}.intro h1{font-family:Manrope,sans-serif;font-size:32px;letter-spacing:-1.3px;font-weight:600;margin:0}.subtitle{font-size:13px;color:var(--muted);margin:8px 0 0}.collection-stat{display:flex;align-items:center;gap:16px;border-left:1px solid var(--line);padding-left:26px;margin-right:4px}.collection-stat strong{font-family:Manrope,sans-serif;font-size:40px;font-weight:500;color:var(--blue);letter-spacing:-2px}.collection-stat span{font-size:11px;line-height:1.6;color:var(--muted)}.workspace{display:grid;grid-template-columns:224px minmax(0,1fr);gap:28px}.catalogue{min-width:0}.catalogue-head{display:flex;justify-content:space-between;align-items:center;margin-bottom:16px}.catalogue-head .eyebrow{margin:0}.catalogue-head>span:last-child{background:#F2F2F2;padding:2px 7px;border-radius:5px;font-size:11px;color:var(--blue)}.search{display:flex;align-items:center;gap:8px;background:white;border:1px solid var(--line);border-radius:7px;padding:10px}.search svg{width:16px;height:16px;fill:none;stroke:var(--muted);stroke-width:1.7;flex-shrink:0}.search input{width:100%;min-width:0;border:0;background:none;outline:none;font-size:11px;color:var(--ink)}.sort-label{display:flex;align-items:center;gap:5px;font-size:11px;color:var(--muted);margin:13px 1px}.sort-label select{border:0;background:none;color:var(--ink);font-size:11px;max-width:135px}.target-list{height:640px;overflow:auto;scrollbar-width:thin;padding-right:5px}.target-row{display:grid;grid-template-columns:45px 1fr 14px;align-items:center;width:100%;text-align:left;background:transparent;border:1px solid transparent;border-bottom-color:var(--line);padding:10px 8px;gap:9px;border-radius:5px}.target-row:hover{background:#F5F5F5}.target-row.active{background:#EDF3FA;border-color:var(--blue);box-shadow:inset 3px 0 var(--blue)}.target-row img{width:44px;height:50px;object-fit:contain}.target-row strong{display:block;font-size:12px}.target-row small{font-size:9px;color:var(--muted);display:block;margin-top:4px}.target-row .arrow{color:#9C9C9C;font-size:13px}.catalogue-foot{font-size:10px;line-height:1.7;color:var(--muted);margin:15px 8px}.detail{min-width:0}.entry-heading{display:flex;justify-content:space-between;gap:16px;min-height:90px;border-bottom:1px solid var(--line);margin-bottom:18px}.entry-heading h2{font-family:Manrope,sans-serif;font-size:31px;letter-spacing:-1px;line-height:1;margin:0 0 8px}.entry-heading .protein-name{font-size:12px;color:var(--muted);max-width:490px;margin:0 0 11px}.entry-links{display:flex;flex-wrap:wrap;gap:13px;font-size:10px;margin-bottom:14px}.entry-links .organism{color:var(--muted);font-style:italic}.entry-badge{align-self:flex-start;color:var(--ink);background:#F2F2F2;border:1px solid #DEDEDE;border-radius:5px;padding:7px 10px;font-size:10px;white-space:nowrap}.detail-grid{display:grid;grid-template-columns:minmax(0,1fr) 220px;gap:18px}.structure-panel{min-width:0;background:white;border:1px solid var(--line);border-radius:9px;overflow:hidden}.panel-toolbar{display:flex;align-items:center;justify-content:space-between;padding:11px 12px;border-bottom:1px solid #E8E8E8;gap:5px}.segmented{display:flex;background:#F3F3F3;padding:3px;border-radius:6px}.segmented button{border:0;background:none;font-size:10px;padding:6px 10px;color:var(--muted);border-radius:4px;white-space:nowrap}.segmented .selected{background:white;box-shadow:0 1px 3px #00000015;color:var(--blue)}.quiet{border:0;background:none;font-size:10px;color:var(--muted);white-space:nowrap}.viewer-wrap{height:372px;position:relative;background:#fff}#viewer{position:absolute;inset:0}.viewer-state{position:absolute;inset:0;display:flex;align-items:center;justify-content:center;font-size:12px;color:var(--muted);background:#ffffffdc;z-index:6;padding:30px;text-align:center}.viewer-state[hidden]{display:none}.viewer-tag{position:absolute;left:16px;top:14px;z-index:2;font-size:8px;letter-spacing:1px;color:#767676;pointer-events:none}.viewer-tag span{margin-left:5px;padding:2px 5px;border:1px solid #DEDEDE;border-radius:3px;font-size:8px}.viewer-controls{display:flex;align-items:center;gap:13px;padding:10px 14px;border-top:1px solid #E8E8E8;font-size:10px;color:var(--muted);flex-wrap:wrap}.viewer-controls select{font-size:10px;border:0;color:var(--ink);background:#F5F5F5;padding:4px;border-radius:4px;max-width:110px}.mouse-hint{margin-left:auto;font-size:9px}.colour-legend{padding:5px 14px 4px;display:flex;gap:14px;align-items:center;font-size:9px;color:var(--muted);min-height:22px}.dot{display:inline-block;width:7px;height:7px;border-radius:50%;margin-right:5px}.crop-note{font-size:9px;color:var(--muted);line-height:1.5;margin:3px 14px 12px}.score-panel{padding:3px 0 0}.score-panel .eyebrow{font-size:9px;margin-bottom:9px}.binder-id{font-size:20px;letter-spacing:-.5px;font-family:Manrope,sans-serif;margin:0 0 5px}.design-name{font-family:ui-monospace,monospace;font-size:9px;line-height:1.6;overflow-wrap:anywhere;color:var(--muted);margin:0 0 14px}.scores{display:grid;grid-template-columns:1fr 1fr;border-top:1px solid var(--line);border-bottom:1px solid var(--line);margin:0 0 15px;padding:14px 0;gap:16px 8px}.metric label{display:block;color:var(--muted);font-size:10px;margin-bottom:4px}.metric strong{font-family:Manrope,sans-serif;font-size:24px;font-weight:500;letter-spacing:-1px}.metric strong small{font-size:10px;margin-left:3px;letter-spacing:0}.metric:last-child strong{color:var(--blue)}.facts{display:grid;grid-template-columns:1fr auto;font-size:10px;gap:10px;margin:0 0 15px}.facts dt{color:var(--muted)}.facts dd{margin:0;font-weight:500;text-align:right}.status-note{font-size:10px;line-height:1.65;background:#F5F5F5;padding:10px;border-radius:5px;margin:0 0 15px;color:#666666}.primary,.download-secondary{display:block;text-align:center;padding:10px 8px;border-radius:5px;font-size:11px;font-weight:500}.primary{background:var(--blue);color:white;border:1px solid var(--blue)}.primary:hover{background:#245894;text-decoration:none}.download-secondary{color:var(--blue);border:1px solid #DEDEDE;background:white;margin-top:8px}.record-link{display:block;font-size:9px;text-align:center;margin-top:11px;color:var(--muted)}.sequence-panel,.evidence-panel{margin-top:23px;background:white;border:1px solid var(--line);border-radius:8px;padding:19px 20px}.section-title{display:flex;justify-content:space-between;align-items:center}.section-title h2,.evidence-panel h2{font-size:14px;font-family:Manrope,sans-serif;font-weight:600;margin:5px 0 17px}.section-title .eyebrow,.evidence-panel .eyebrow{font-size:8px}.section-title>span{font-size:10px;color:var(--muted)}.track{display:grid;grid-template-columns:105px minmax(0,1fr);align-items:center;gap:12px;margin-bottom:13px}.track-label{font-size:10px;color:var(--muted)}.track svg{width:100%;height:22px;overflow:visible}.track button{height:20px;width:100%;padding:0;background:none;border:0;text-align:left}.track button:hover{filter:brightness(.9)}.track-axis{display:flex;justify-content:space-between;font-size:9px;color:#767676;margin-left:117px;margin-top:-7px;margin-bottom:14px}.small-note{font-size:10px;line-height:1.7;color:var(--muted);margin:8px 0 0}.sequence-details{border-top:1px solid var(--line);margin-top:13px;padding-top:13px}.sequence-details summary{cursor:pointer;font-size:10px;color:var(--blue)}.sequence-details pre{white-space:pre-wrap;word-break:break-all;line-height:1.8;font-size:10px;color:#666666;max-height:170px;overflow:auto;background:var(--bg);padding:10px}.sequence-details h3{font-size:11px;font-weight:500;margin-top:16px}.evidence-panel{display:grid;grid-template-columns:1fr 1fr;gap:0 30px}.evidence-panel p{font-size:10px;color:var(--muted);line-height:1.7}.evidence-panel .small-note{grid-column:1/-1;border-top:1px solid var(--line);padding-top:10px}.comparison-row{display:grid;grid-template-columns:60px 1fr 32px;gap:8px;align-items:center;font-size:10px;margin:10px 0;color:var(--muted)}.comparison-row .bar{height:7px;background:#F2F2F2;border-radius:4px;overflow:hidden}.comparison-row .bar i{display:block;height:100%;border-radius:4px;background:#9C9C9C}.comparison-row:last-child .bar i{background:var(--blue)}.comparison-row strong{font-weight:500;color:var(--ink);text-align:right}.entry-footer{display:flex;justify-content:space-between;gap:15px;font-size:9px;color:var(--muted);padding:23px 0 26px}dialog{max-width:650px;width:calc(100% - 30px);max-height:85vh;overflow:auto;border:1px solid var(--line);border-radius:12px;padding:30px;box-shadow:0 20px 90px #00000030;color:var(--ink)}dialog::backdrop{background:#00000060;backdrop-filter:blur(3px)}dialog h2{font-family:Manrope,sans-serif;font-size:24px;letter-spacing:-.8px}dialog h3{font-size:13px;margin:22px 0 7px}dialog p{font-size:12px;line-height:1.85;color:#666666}dialog .close{float:right;background:none;border:0;font-size:25px;color:var(--muted)}dialog .primary{margin-top:20px}#toast{position:fixed;bottom:20px;left:50%;transform:translateX(-50%);background:var(--ink);color:white;font-size:12px;padding:10px 18px;border-radius:6px;opacity:0;pointer-events:none;z-index:100}.empty{padding:30px 10px;color:var(--muted);font-size:12px;line-height:1.8}.msp-plugin{font-family:inherit!important}.msp-plugin .msp-layout-standard{border:0!important}.msp-plugin .msp-viewport{border:0!important}.msp-plugin .msp-viewport-controls{top:42px!important;right:10px!important}.msp-plugin .msp-viewport-controls .msp-btn-icon{background:#F5F5F5!important;color:#666666!important}.msp-plugin .msp-highlight-toast-wrapper{font-size:10px!important}.msp-plugin .msp-logo{display:none!important}
@media(min-width:1450px){.viewer-wrap{height:420px}.target-list{height:700px}.detail-grid{grid-template-columns:minmax(0,1fr) 245px}}
@media(max-width:1150px){.header{padding:0 24px;gap:25px}main{padding:27px 24px 0}.workspace{grid-template-columns:180px minmax(0,1fr);gap:19px}.detail-grid{grid-template-columns:minmax(0,1fr) 185px;gap:13px}.viewer-wrap{height:340px}.mouse-hint{display:none}.release{font-size:9px}.target-row{grid-template-columns:32px 1fr 8px;padding:10px 4px;gap:7px}.target-row img{width:30px}.score-panel .metric strong{font-size:21px}.panel-toolbar{padding:10px 7px}.segmented button{padding:6px 7px;font-size:9px}.quiet{font-size:9px}}
@media(max-width:850px){.release{display:none}.workspace{grid-template-columns:155px minmax(0,1fr);gap:15px}.detail-grid{grid-template-columns:1fr}.score-panel{display:grid;grid-template-columns:1fr 1fr;gap:0 16px;padding:8px}.scores{grid-column:1/-1;grid-template-columns:repeat(4,1fr);margin-top:10px}.score-panel>.eyebrow,.binder-id,.design-name{grid-column:1/-1}.design-name{margin-bottom:0}.record-link{grid-column:1/-1}.target-row{grid-template-columns:1fr 10px}.target-row img{display:none}.viewer-wrap{height:360px}.entry-badge{font-size:8px;padding:5px}.intro h1{font-size:27px}.collection-stat{padding-left:15px}.collection-stat strong{font-size:30px}.collection-stat span{font-size:9px}.evidence-panel{grid-template-columns:1fr}.entry-footer{flex-direction:column}.status-note{margin-bottom:10px}.facts{margin-bottom:10px}}
@media(max-width:600px){.header{height:65px;padding:0 17px;gap:20px}.brand strong{font-size:18px}.brand svg{width:27px;height:27px}.brand{gap:7px}.brand strong span{margin-left:4px}nav{gap:14px;margin-left:auto}nav a,nav button{font-size:10px}main{padding:22px 16px 0}.intro{margin-bottom:22px}.intro h1{font-size:26px}.intro .eyebrow{font-size:8px;letter-spacing:1.3px}.subtitle{font-size:11px}.collection-stat{display:none}.workspace{display:block}.catalogue-head{margin-bottom:10px}.catalogue{margin-bottom:22px}.sort-label{margin:10px 0}.target-list{height:62px;display:flex;gap:7px;overflow-x:auto;padding:0 0 6px}.target-row{flex:0 0 100px;padding:8px;border:1px solid var(--line)}.target-row small{font-size:8px}.catalogue-foot{display:none}.entry-heading h2{font-size:27px}.entry-heading .protein-name{font-size:11px}.entry-heading{min-height:90px}.viewer-wrap{height:350px}.score-panel{padding:9px 0}.sequence-panel,.evidence-panel{padding:17px 13px}.track{grid-template-columns:83px 1fr;gap:8px}.track-label{font-size:9px}.track-axis{margin-left:91px}.section-title h2{font-size:12px}.section-title>span{font-size:9px}.colour-legend{flex-wrap:wrap}.entry-footer{line-height:1.7}}


.msp-plugin .msp-state-snapshot-viewport-controls{display:none!important}

[hidden]{display:none!important}.collection-stat span span{display:inline}.target-monogram{display:grid;place-items:center;width:40px;height:44px;border-radius:5px;background:#F2F2F2;color:#666666;font:500 12px Manrope,sans-serif}.binder-browser{background:#fff;border:1px solid var(--line);border-radius:7px;padding:13px 15px;margin-bottom:18px}.binder-select-wrap label{display:block;font-size:9px;letter-spacing:1.2px;color:var(--muted);font-weight:700;margin-bottom:8px}.binder-select-wrap label span{float:right;letter-spacing:0;font-weight:400}.binder-select-wrap select{width:100%;padding:8px;border:1px solid var(--line);border-radius:4px;background:#FFFFFF;color:var(--ink);font-family:ui-monospace,monospace;font-size:11px}.binder-filters{display:flex;align-items:center;gap:16px;flex-wrap:wrap;margin-top:10px}.binder-filters>input{min-width:150px;flex:1;border:0;border-bottom:1px solid var(--line);padding:6px 3px;font-size:11px;color:var(--ink)}.binder-filters label{font-size:10px;color:var(--muted);display:flex;align-items:center;gap:4px}.binder-filters input[type=checkbox]{accent-color:var(--blue)}.compact-id{font-size:14px;letter-spacing:0;overflow-wrap:anywhere}.entry-badge.caution{color:#896d33;background:#faf4e6;border-color:#eadfc6;font-size:9px}.metric-warning{font-size:10px;line-height:1.7;color:#896d33;background:#faf5e9;border-left:2px solid #c5a560;padding:9px;margin:0 0 13px}.pae-panel{margin-top:23px;background:white;border:1px solid var(--line);border-radius:8px;padding:19px 20px}.pae-unit{color:var(--muted);font-weight:400;margin-left:4px}.pae-panel .section-title a{font-size:10px}.pae-toolbar{display:flex;justify-content:space-between;gap:12px;align-items:center;border-top:1px solid #E8E8E8;padding:11px 0;color:var(--muted);font-size:10px}.pae-toolbar select{font-size:10px;color:var(--ink);padding:5px;background:#F5F5F5;border:1px solid var(--line);border-radius:4px;max-width:240px}.pae-grid{display:grid;grid-template-columns:minmax(0,1fr) 210px;gap:20px;align-items:center}.pae-plot{position:relative;padding-left:10px}.pae-canvas-wrap{max-width:590px;margin:auto}#pae-canvas{display:block;width:100%;height:auto;aspect-ratio:1;touch-action:none;cursor:crosshair}.pae-axis-y{position:absolute;left:-11px;top:48%;writing-mode:vertical-rl;transform:rotate(180deg);font-size:10px;color:var(--muted)}.pae-axis-x{display:block;text-align:center;font-size:10px;color:var(--muted);margin-top:-8px}.pae-info{font-size:11px;color:var(--muted);line-height:1.7}.pae-scale{height:10px;background:linear-gradient(90deg,rgb(12,83,64),rgb(242,248,245));border-radius:2px;margin-top:15px}.pae-scale-labels{display:flex;justify-content:space-between;font-size:9px}.pae-info .eyebrow{font-size:9px}.pae-status{padding:32px 15px;text-align:center;color:var(--muted);font-size:12px;line-height:1.7;background:#F5F5F5;border-radius:5px;margin:10px 0}.pae-value{display:block;font-family:Manrope,sans-serif;font-size:29px;color:#27684d;font-weight:500;line-height:1.8}.pae-value small{font-size:10px}#pae-readout{border-top:1px solid var(--line);border-bottom:1px solid var(--line);padding:15px 0;margin:18px 0;min-height:100px;font-size:11px}#pae-readout span{display:flex;justify-content:space-between}#pae-chains{font-size:10px}#show-pair{padding:4px 0;font-size:10px;color:var(--blue);white-space:normal;text-align:left}.catalogue .target-list{height:720px}
@media(max-width:1150px){.pae-grid{grid-template-columns:minmax(0,1fr) 160px;gap:12px}.binder-filters{gap:9px}.target-monogram{width:30px}.pae-panel{padding:15px}.pae-toolbar select{max-width:200px}}
@media(max-width:850px){.target-monogram{display:none}.pae-grid{grid-template-columns:1fr}.pae-info{display:grid;grid-template-columns:1fr 1fr;gap:0 18px}.pae-info>.eyebrow,.pae-info>p:first-of-type{grid-column:1/-1}.pae-scale,.pae-scale-labels{grid-column:1/-1}#pae-readout{grid-row:5/8}.pae-info .small-note{margin-top:14px}.pae-toolbar{flex-wrap:wrap}.entry-badge{max-width:145px;white-space:normal;line-height:1.5}.binder-select-wrap select{font-size:10px}}
@media(max-width:600px){.catalogue .target-list{height:62px}.pae-panel{padding:15px 12px}.pae-panel .section-title{align-items:flex-start;gap:10px}.pae-panel .section-title a{font-size:9px;max-width:85px;text-align:right;line-height:1.5}.pae-panel .section-title h2{font-size:13px}.pae-toolbar select{max-width:195px}.pae-grid{gap:8px}.pae-info{font-size:10px}.entry-badge.caution{max-width:125px;font-size:8px}}

.intro{margin-bottom:23px}.intro h1{font-size:25px}.entry-heading{min-height:0;padding-bottom:17px;margin-bottom:0;align-items:flex-start}.entry-heading h2{font-size:27px;line-height:1.25;letter-spacing:-.7px;max-width:850px;margin-bottom:12px}.entry-heading .eyebrow{font-size:10px;margin-bottom:9px}.entry-heading .entry-links{margin-bottom:0}.protein-overview{display:grid;grid-template-columns:1fr 1fr;gap:20px 34px;padding:24px 0;margin-bottom:4px}.protein-overview dl{display:grid;grid-template-columns:145px 1fr;gap:11px 14px;font-size:12px;line-height:1.5;margin:13px 0 0}.protein-overview dt{color:var(--muted)}.protein-overview dd{margin:0;color:var(--ink)}.overview-note{grid-column:1/-1;margin:0;font-size:11px}.binder-actions{display:flex;gap:18px;align-items:center;justify-content:space-between}.apo-choice{font-size:12px;background:#F5F5F5;border:1px solid var(--line);border-radius:5px;padding:10px 15px;white-space:nowrap}.apo-choice.selected{background:#EDF3FA;border-color:#2E6FBA;color:var(--blue)}.quick-select{display:flex!important;align-items:center;gap:10px;min-width:0;max-width:65%;margin:0!important;letter-spacing:0!important;font-weight:400!important}.quick-select select{min-width:0;font-size:10px}.binder-table{max-height:222px;overflow:auto;margin-top:13px;border-top:1px solid var(--line);scrollbar-width:thin}.binder-table table{border-collapse:collapse;width:100%;text-align:left;font-size:11px;white-space:nowrap}.binder-table th{position:sticky;top:0;z-index:1;background:#F5F5F5;padding:10px;font-weight:500;color:var(--muted);font-size:10px}.binder-table td{border-top:1px solid #E8E8E8;padding:7px 10px}.binder-table td:first-child{width:55%}.binder-table button{padding:3px 0;background:none;border:0;font-family:ui-monospace,monospace;font-size:11px;text-align:left;color:var(--blue)}.binder-table button small{display:block;font-family:inherit;font-size:9px;color:#96753e;margin-top:3px}.binder-table tr:hover{background:#F5F5F5}.binder-table tr.chosen{background:#EDF3FA}.binder-table tr.chosen td:first-child{box-shadow:inset 3px 0 var(--blue)}.apo-mean{border-top:1px solid var(--line);padding-top:20px;margin-top:20px;display:flex;justify-content:space-between;align-items:center;font-size:11px;color:var(--muted)}.apo-mean strong{font:500 30px Manrope,sans-serif;color:var(--ink)}.confidence-bins{margin:20px 0 25px}.confidence-bins>div{display:flex;gap:7px;align-items:center;font-size:10px;margin:12px 0}.confidence-bins i{width:8px;height:8px;border-radius:2px}.confidence-bins b{margin-left:auto;font-weight:500}.confidence-bins small{color:var(--muted);margin-left:4px}.score-panel>.status-note{margin-top:15px}.score-panel>.small-note{margin-bottom:15px}
@media(max-width:1150px){.protein-overview{gap:18px}.protein-overview dl{grid-template-columns:120px 1fr;font-size:11px;gap:9px}.entry-heading h2{font-size:24px}.binder-actions{gap:10px}.apo-choice{font-size:10px;padding:9px}.quick-select{max-width:60%}}
@media(max-width:850px){.protein-overview{grid-template-columns:1fr}.overview-note{grid-column:auto}.protein-overview>div+div{border-top:1px solid var(--line);padding-top:15px}.apo-mean,.confidence-bins{grid-column:1/-1}.apo-mean{margin:10px 0 0}.confidence-bins{display:grid;grid-template-columns:1fr 1fr;gap:0 20px;margin:4px 0 20px}.score-panel .metric-warning{grid-column:1/-1}.binder-actions{flex-wrap:wrap}.quick-select{max-width:100%;width:100%}.binder-table{max-height:190px}}
@media(max-width:600px){.entry-heading{gap:10px}.entry-heading h2{font-size:23px}.protein-overview{padding:20px 0}.protein-overview dl{font-size:12px;grid-template-columns:140px 1fr}.binder-browser{padding:13px 11px}.binder-table table{font-size:10px}.binder-table button{font-size:10px}.binder-table td,.binder-table th{padding:8px}.intro h1{font-size:24px}}


.workspace{display:block}
.target-page .intro{display:none}
.catalogue-page .detail{position:absolute;left:-100000px;top:0;width:100%;visibility:hidden;pointer-events:none}
.back-catalogue{display:inline-block;font-size:12px;margin:0 0 24px}
.catalogue{margin:0 0 32px}
.catalogue-head{margin-bottom:18px}
.catalogue .search{max-width:540px;padding:13px}
.catalogue .search input{font-size:14px}
.catalogue .sort-label{margin:18px 0;font-size:12px}
.catalogue .sort-label select{font-size:12px}
.catalogue .target-list{height:auto;display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:14px;overflow:visible;padding:0}
.catalogue .target-row{display:grid;grid-template-columns:64px minmax(0,1fr) 14px;gap:14px;border:1px solid var(--line);border-radius:7px;padding:20px 16px;color:var(--ink);text-decoration:none;align-items:center}
.catalogue .target-row:hover{border-color:var(--blue);background:#FAFAFA}
.catalogue .target-row strong{font-size:17px;color:var(--blue)}
.catalogue .target-row small{font-size:11px;margin-top:8px;line-height:1.5}
.target-card-name{display:block;font-size:12px;line-height:1.5;margin-top:7px}
.target-card-image img{display:block!important;width:64px!important;height:78px!important;object-fit:contain}
.target-monogram{display:grid!important;width:60px;height:70px;font-size:17px}
.catalogue-foot{display:block;margin:20px 0}
.detail-grid{display:grid;grid-template-columns:minmax(0,1.15fr) minmax(0,1fr);gap:20px;align-items:start}
.detail-grid .pae-panel{margin:0;padding:16px;min-width:0}
.detail-grid .pae-grid{display:block}
.detail-grid .pae-info{display:block}
.detail-grid .pae-info>.eyebrow,.detail-grid .pae-info>p:first-of-type{display:none}
.detail-grid .pae-scale{margin-top:8px}
.detail-grid #pae-readout{min-height:0;margin:10px 0;padding:10px 0;font-size:11px}
.detail-grid .pae-value{font-size:22px;line-height:1.4}
.detail-grid #pae-chains{display:flex;gap:24px}
.detail-grid .section-title{align-items:start;gap:10px}
.detail-grid .section-title h2{font-size:14px;line-height:1.4;margin-bottom:12px}
.detail-grid .section-title a{font-size:10px;text-align:right;max-width:100px;line-height:1.5}
.detail-grid .pae-toolbar{flex-wrap:wrap;gap:7px}
.detail-grid .pae-toolbar select{max-width:210px}
.detail-grid .viewer-wrap{height:460px}
.detail-grid .mouse-hint{display:none}
.score-panel{margin-top:22px;padding:20px;border:1px solid var(--line);border-radius:8px;display:grid;grid-template-columns:1fr 1fr;gap:0 24px}
.score-panel>.eyebrow,.score-panel>.binder-id,.score-panel>.design-name,.score-panel>.scores,.score-panel>.metric-warning,.score-panel>.record-link{grid-column:1/-1}
.score-panel>.scores{grid-template-columns:repeat(4,1fr);margin-top:14px}
.score-panel>.primary,.score-panel>.download-secondary{align-self:start;margin-top:8px}
.score-panel>.apo-mean{margin-top:10px}
.score-panel>.confidence-bins{grid-column:auto}
.linked-sequence{border:1px solid var(--line);border-radius:8px;padding:16px 18px;margin:0 0 18px;min-width:0}
.linked-sequence h2{margin:0;font-size:14px}
.sequence-lane{min-width:0;margin-top:14px}
.sequence-chain{font-size:11px;color:var(--muted);margin-bottom:5px}
.sequence-strip{display:flex;flex-wrap:wrap;gap:18px 0;overflow:visible;white-space:normal;padding:20px 0 7px}
.residue{flex:0 0 14px;position:relative;display:inline-block;width:14px;height:23px;padding:0;border:0;border-radius:2px;background:transparent;font:13px/23px ui-monospace,SFMono-Regular,Consolas,monospace;color:var(--ink);vertical-align:top}
.residue::before{content:attr(data-number);position:absolute;top:-18px;left:50%;transform:translateX(-50%);font:9px/14px ui-monospace,monospace;color:#767676;pointer-events:none}
.residue:first-child::before{left:0;transform:none}
.residue.outside{color:#BDBDBD}
.residue:hover,.residue-active{background:var(--blue);color:white}
.residue.outside:hover,.residue.outside.residue-active{background:#EEEEEE;color:#999999}
#residue-readout{font-size:11px;line-height:1.6;color:var(--muted);margin:12px 0 0;min-height:18px}
@media(min-width:701px) and (max-width:850px){.protein-overview{grid-template-columns:1fr 1fr;gap:20px}.protein-overview>div+div{border-top:0;padding-top:0}.protein-overview dl{grid-template-columns:110px 1fr;font-size:11px}.overview-note{grid-column:1/-1}}
@media(max-width:1100px){.catalogue .target-list{grid-template-columns:repeat(2,minmax(0,1fr))}.detail-grid{gap:14px;grid-template-columns:minmax(0,1fr) minmax(0,1fr)}.detail-grid .viewer-wrap{height:380px}.detail-grid .pae-panel{padding:12px}}
@media(max-width:700px){.detail-grid{grid-template-columns:1fr}.detail-grid .viewer-wrap{height:360px}.catalogue .target-list{grid-template-columns:1fr}.score-panel{padding:14px;gap:0 14px}.score-panel>.scores{gap:10px}.metric strong{font-size:21px}.linked-sequence{padding:13px 12px}.protein-overview dl{grid-template-columns:125px 1fr}}


.detail-grid{--binder-width:220px;grid-template-columns:var(--binder-width) minmax(0,1.15fr) minmax(0,1fr);gap:16px}
.detail-grid.binders-collapsed{--binder-width:42px}
.detail-grid .binder-browser{min-width:0;padding:0;margin:0;align-self:start}
.binder-browser summary{display:flex;align-items:center;gap:9px;list-style:none;padding:13px 12px;cursor:pointer;font-size:12px;font-weight:600;color:var(--ink)}
.binder-browser summary::-webkit-details-marker{display:none}
.binder-chevron{font-size:22px;line-height:18px;color:var(--blue)}
.binder-summary-label{display:flex;align-items:center;gap:7px}
.binder-summary-label #binder-count{font-size:10px;color:var(--muted);font-weight:400}
.binder-browser:not([open]) summary{flex-direction:column;padding:13px 8px}
.binder-browser:not([open]) .binder-chevron{transform:rotate(180deg)}
.binder-browser:not([open]) .binder-summary-label{writing-mode:vertical-rl;margin-top:7px}
.binder-browser-content{padding:0 10px 12px}
.binder-browser .apo-choice{width:100%;font-size:11px;padding:8px}
.binder-browser .binder-table{max-height:475px;margin-top:12px;overflow:auto}
.binder-browser table{table-layout:fixed;white-space:normal}
.binder-browser .binder-table th,.binder-browser .binder-table td{padding:10px 6px;vertical-align:top}
.binder-browser .binder-table th:last-child,.binder-browser .binder-table td:last-child{width:45px;text-align:right;font-variant-numeric:tabular-nums}
.binder-browser .binder-table td:first-child{width:auto}
.binder-browser .binder-table button{font:11px/1.65 'DM Sans',system-ui,sans-serif;overflow-wrap:anywhere;width:100%}
.detail-grid .panel-toolbar{flex-wrap:wrap}
.detail-grid .pae-toolbar select{max-width:100%}
.detail-grid .pae-toolbar label{max-width:100%;min-width:0}
@media(max-width:1100px){.detail-grid{--binder-width:180px;gap:12px}.detail-grid .viewer-wrap{height:380px}}
@media(max-width:760px){.detail-grid,.detail-grid.binders-collapsed{grid-template-columns:1fr}.binder-browser:not([open]) summary{flex-direction:row}.binder-browser:not([open]) .binder-summary-label{writing-mode:horizontal-tb;margin-top:0}.binder-browser:not([open]) .binder-chevron{transform:rotate(-90deg)}.binder-browser .binder-table{max-height:250px}.detail-grid .viewer-wrap{height:360px}}


.sequence-chain{display:flex;justify-content:space-between;align-items:center;gap:12px;margin-bottom:5px}
.copy-sequence{color:var(--blue);font-size:10px;padding:3px 0}
.sequence-strip{gap:4px 7px;padding:0;background:#F7F7F7}
.sequence-block{position:relative;display:flex;flex:0 0 auto;padding-top:11px}
.sequence-block::before{content:attr(data-start);position:absolute;top:0;left:0;color:#888;font:8px/11px ui-monospace,monospace}
.sequence-block .residue{flex:0 0 8px;width:8px;height:16px;font-size:11px;line-height:16px}
.residue::before{content:none}
.residue.region-selected{background:#DAE8F4;color:#245894}
.residue.region-selected:hover,.residue.region-selected.residue-active{background:var(--blue);color:white}
.sequence-panel{margin:0 0 18px;padding:15px 18px}
.sequence-panel .section-title h2{margin:0 0 12px}
.region-facts{display:grid;grid-template-columns:repeat(3,1fr);gap:12px;margin:0 0 13px}
.region-facts span{display:block;font-size:10px;color:var(--muted);margin-bottom:5px}
.region-facts strong{font-size:14px;font-weight:500}
.interface-confidence{display:flex;flex-wrap:wrap;align-items:baseline;gap:10px 20px;font-size:11px;border-top:1px solid var(--line);padding-top:10px}
.interface-confidence>span:first-child{color:var(--muted)}
#binding-summary>.small-note{font-size:9px;margin-bottom:16px}
.annotation-row{display:grid;grid-template-columns:125px minmax(0,1fr);gap:12px;align-items:center;margin:12px 0}
.annotation-row .small-note{margin:0}
.annotation-rail{height:18px;position:relative;background:linear-gradient(transparent 5px,#F0F0F0 5px,#F0F0F0 13px,transparent 13px)}
.annotation-block{position:absolute;top:3px;height:12px;min-width:3px;border:0;padding:0;border-radius:2px;background:#B5D0E7}
.annotation-block.segment{background:#2E6FBA}
.annotation-block.contacts{background:#555}
.annotation-block:hover,.annotation-block[aria-pressed=true]{outline:2px solid #222;outline-offset:2px;z-index:1}
.annotation-block:disabled{cursor:default;opacity:.5}
.annotation-axis{margin-left:137px;margin-top:0;margin-bottom:10px}
.entry-actions{display:flex;align-items:start;justify-content:space-between;gap:15px;margin-bottom:20px}
.entry-actions .back-catalogue{margin:9px 0 0}
.entry-downloads{position:relative;z-index:30;font-size:12px}
.entry-downloads summary{list-style:none;cursor:pointer;background:var(--blue);color:#fff;padding:10px 16px;border-radius:4px;display:flex;gap:25px}
.entry-downloads summary::-webkit-details-marker{display:none}
#download-items{position:absolute;right:0;top:100%;width:285px;padding:8px 0;margin-top:5px;border:1px solid var(--line);border-radius:5px;background:white;box-shadow:0 8px 25px #00000018}
#download-items p{font-size:10px;color:var(--muted);padding:5px 13px;margin:0;overflow-wrap:anywhere}
#download-items a,.download-unavailable{display:block;padding:10px 13px;font-size:11px}
#download-items a:hover{background:#EDF3FA;text-decoration:none}
#download-items a span{float:right}
.download-unavailable{color:#888}
@media(max-width:600px){.region-facts{grid-template-columns:1fr 1fr}.annotation-row{grid-template-columns:98px minmax(0,1fr);gap:8px}.annotation-axis{margin-left:106px}.entry-downloads summary{gap:12px;padding:9px 11px}.sequence-panel{padding:13px 12px}.sequence-chain{font-size:10px}.linked-sequence .section-title>span{font-size:8px}}


.detail-grid{grid-template-columns:var(--binder-width) minmax(0,1fr) minmax(0,320px)}
.detail-grid .pae-panel{padding:14px}
.detail-grid .pae-toolbar{padding:8px 0}
.detail-grid .pae-canvas-wrap{max-width:290px}
.detail-grid #pae-chains{gap:14px}
.detail-grid .colour-legend{flex-wrap:wrap;gap:7px 12px}
.sr-only{position:absolute!important;width:1px!important;height:1px!important;padding:0!important;margin:-1px!important;overflow:hidden!important;clip:rect(0,0,0,0)!important;white-space:nowrap!important;border:0!important}
@media(max-width:1100px) and (min-width:761px){.detail-grid{--binder-width:155px;grid-template-columns:var(--binder-width) minmax(0,1fr) minmax(0,250px)}.detail-grid .pae-panel{padding:10px}}
@media(max-width:760px){.detail-grid,.detail-grid.binders-collapsed{grid-template-columns:1fr}.detail-grid .pae-panel{width:100%;max-width:340px;justify-self:center}}

.residue:not(.outside).pae-row-selected{background:#13918135;color:#12594e}.residue:not(.outside).pae-col-selected{background:#ef863c45;color:#7b3c0d}

.pae-help{margin-top:12px;font-size:10px}.pae-help summary{cursor:pointer;color:var(--muted)}


#pae-readout:empty{display:none}

.colour-legend.pae-active>span:not(.pae-selection-legend){display:none}
.residue.pae-muted{color:#aaa!important;background:transparent!important}


.protein-overview{display:block;padding:0 0 20px;margin-bottom:0;border:0}
.overview-stats{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:15px;margin:0}
.protein-overview .overview-stats{grid-template-columns:repeat(4,minmax(0,1fr))}
.overview-stats dt{font-size:11px;color:var(--muted);margin:0 0 6px}
.overview-stats dd{font-size:17px;margin:0;line-height:1.3}
.protein-overview .overview-note{margin:12px 0 0;padding:0}
.linked-sequence{border:0;border-top:1px solid var(--line);border-radius:0;padding:18px 0}
.sequence-panel{border:0;border-top:1px solid var(--line);border-radius:0;padding:20px 0;margin-top:22px}
.binder-score-line{display:flex;align-items:center;justify-content:space-between;gap:20px;flex-wrap:wrap;margin:0 0 18px}
.selected-binder-id{font-size:12px;font-weight:600;overflow-wrap:anywhere}
.binder-score-line dl{display:flex;gap:30px;flex-wrap:wrap;margin:0}
.binder-score-line dl>div{display:flex;align-items:baseline;gap:9px}
.binder-score-line dt{font-size:11px;color:var(--muted)}
.binder-score-line dd{font-size:18px;margin:0}.binder-score-line small{font-size:10px}
.entry-provenance{margin-top:16px;font-size:11px;color:var(--muted)}
.entry-provenance summary{cursor:pointer;padding:5px 0}
.provenance-facts{display:grid;grid-template-columns:130px minmax(0,1fr);gap:8px 15px;margin:12px 0}
.provenance-facts dd{margin:0;overflow-wrap:anywhere}
.entry-provenance .confidence-bins{max-width:340px}
@media(max-width:600px){.protein-overview .overview-stats{grid-template-columns:repeat(2,minmax(0,1fr));gap:14px}.binder-score-line{gap:12px}.binder-score-line dl{gap:14px}.binder-score-line dd{font-size:16px}.provenance-facts{grid-template-columns:100px minmax(0,1fr)}}


.home-page .header,.catalogue-page .header{display:none}
.home-page .detail{position:absolute;left:-100000px;top:0;width:100%;visibility:hidden;pointer-events:none}
.home-page main{max-width:1440px;padding:0 52px}
.cover{min-height:100svh;display:flex;flex-direction:column}
.cover-wordmark{font:600 25px Manrope,sans-serif;color:var(--ink);letter-spacing:-1px;padding-top:38px;align-self:flex-start}
.cover-wordmark span{font-weight:400;color:var(--blue)}
.cover-layout{flex:1;display:grid;grid-template-columns:1fr 1fr;gap:24px;align-items:center;padding:55px 0 45px}
.cover-kicker{font-size:11px;letter-spacing:2px;color:var(--blue);font-weight:600;margin-bottom:24px}
.cover h1{font:500 clamp(58px,6.6vw,96px)/1.02 Manrope,sans-serif;letter-spacing:-5px;margin:0 0 28px}
.cover-description{font-size:17px;line-height:1.7;color:var(--muted);margin-bottom:34px}
.cover-cta{display:inline-flex;align-items:center;gap:45px;background:var(--blue);color:white;border-radius:3px;padding:16px 22px;font-size:14px;text-decoration:none!important}
.cover-cta:hover{background:#245894}.cover-cta span{font-size:22px;line-height:1}
.cover-figure{margin:0;min-width:0}
.cover-structure{height:520px;display:block;position:relative;overflow:hidden;background:transparent}
.cover-structure img{position:absolute;max-width:none;width:230%;height:auto;left:50%;top:50%;transform:translate(-50%,-50%)}
.cover-figure figcaption{display:flex;justify-content:space-between;gap:15px;border-top:1px solid var(--line);padding-top:16px;font-size:11px;color:var(--muted)}
.cover-footer{border-top:1px solid var(--line);display:flex;justify-content:space-between;padding:24px 0;font-size:11px;color:var(--muted)}
.cover-footer div{display:flex;gap:24px}.cover-footer button{border:0;padding:0;background:none;color:inherit;font-size:inherit}.cover-footer a{color:inherit}
.catalogue-page main{max-width:1380px;padding-top:38px}
.catalogue-heading .back-home{font-size:12px;color:var(--muted)}
.catalogue-heading h1{font:500 34px Manrope,sans-serif;letter-spacing:-1px;margin:27px 0 22px}
.catalogue-heading h1 span{font:400 13px system-ui;color:var(--muted);letter-spacing:0;margin-left:8px;vertical-align:middle}
.catalogue-controls{display:flex;align-items:center;gap:24px;margin-bottom:26px;justify-content:space-between}
.catalogue-controls .search{flex:1;max-width:600px;padding:11px 13px}
.catalogue-controls .sort-label{margin:0;gap:6px;white-space:nowrap}
.catalogue-controls .sort-label select{max-width:175px;padding:6px 0}
.catalogue .target-row{grid-template-columns:minmax(0,1fr) 14px;min-height:132px;padding:18px 20px;border-radius:3px}
.catalogue .target-row strong{font-size:17px}.target-card-name{min-height:36px;margin:6px 0 12px}
.target-card-meta{display:flex;justify-content:space-between;gap:10px;font-size:11px;color:var(--muted)}
@media(max-width:850px){.home-page main{padding:0 26px}.cover-layout{gap:10px}.cover h1{font-size:62px;letter-spacing:-3px}.cover-description{font-size:14px}.cover-structure{height:420px}.cover-kicker{font-size:9px;letter-spacing:1.3px}}
@media(max-width:600px){.cover-layout{grid-template-columns:1fr;padding:42px 0 25px}.cover-wordmark{padding-top:25px;font-size:22px}.cover h1{font-size:59px}.cover-structure{height:340px;max-width:370px;margin:auto}.cover-footer{gap:20px}.cover-footer div{gap:15px}.catalogue-controls{align-items:stretch;flex-direction:column;gap:12px}.catalogue-controls .sort-label{align-self:flex-end}.catalogue-heading h1{font-size:29px}.catalogue-page main{padding-top:24px}}


#crop-note:empty{display:none}


.profile-summary-heading{font-size:12px;font-weight:600;background:#f5f5f5;padding:12px 16px;margin:0 0 19px;border-left:3px solid var(--blue)}
.profile-columns{display:grid;grid-template-columns:minmax(0,1fr) minmax(0,1fr);gap:36px;padding:0 14px}
.protein-overview .profile-fields{display:grid;grid-template-columns:145px minmax(0,1fr);gap:10px 18px;margin:0;font-size:12px;line-height:1.6;align-content:start}
.profile-fields dt{font-weight:500;color:var(--ink)}
.profile-fields dd{margin:0;overflow-wrap:anywhere}
.overview-confidence{display:grid;gap:5px}
.overview-confidence>div{display:flex;align-items:center;gap:7px}
.overview-confidence i{width:12px;height:12px;display:block;flex-shrink:0}
@media(max-width:1050px){.profile-columns{gap:24px;padding:0 6px}.protein-overview .profile-fields{grid-template-columns:125px minmax(0,1fr);gap:9px 12px}}
@media(max-width:650px){.profile-columns{grid-template-columns:1fr;gap:22px}.protein-overview .profile-fields{grid-template-columns:135px minmax(0,1fr)}}

.cover-top{display:flex;align-items:center;justify-content:space-between;padding-top:32px;gap:20px}
.cover-wordmark{padding-top:0}.cover-top-link{font-size:12px;color:var(--muted)}.cover-top-link span{margin-left:16px;color:var(--blue)}
.cover-layout{grid-template-columns:minmax(330px,.85fr) minmax(0,1.15fr);gap:8px;padding:48px 0 32px}
.cover-kicker{font-size:10px;letter-spacing:2.4px;margin-bottom:30px}
.cover h1{font-size:clamp(62px,7.4vw,106px);font-weight:500;line-height:1.04;letter-spacing:-5.6px;margin-bottom:28px}
.cover h1 em{font-style:normal;color:var(--blue)}
.cover-description{font-size:15px;line-height:1.9;max-width:380px;margin-bottom:30px}
.cover-cta{border-radius:30px;padding:15px 24px;gap:35px;box-shadow:0 5px 18px #2e6fba12;transition:background .2s,transform .2s}
.cover-cta:hover{transform:translateY(-2px)}
.cover-key{display:flex;flex-wrap:wrap;gap:12px 17px;margin-top:38px;font-size:10px;color:var(--muted);max-width:330px}
.cover-key span{display:inline-flex;gap:6px;align-items:center}.cover-key i{width:7px;height:7px;border-radius:50%}.key-binder{background:#217ccf}.key-bound{background:#ea9a3e}.key-free{background:#b3bac4}
.cover-structure{height:clamp(400px,48vw,610px);background:transparent;overflow:hidden}
.cover-structure canvas{width:100%;height:100%;display:block}
.cover-structure canvas[hidden],.cover-structure img[hidden]{display:none}
.cover-structure img{position:absolute;inset:0;transform:none;width:100%;height:100%;object-fit:contain;max-width:100%}
.cover-motion-toggle{position:absolute;right:12px;bottom:15px;border:1px solid #dce2e9;border-radius:22px;padding:8px 13px;background:#ffffffdf;color:#586577;font-size:10px;backdrop-filter:blur(8px)}
.cover-motion-toggle:hover{border-color:#2e6fba;color:#2e6fba}
.cover-figure figcaption{font-size:10px;padding:15px 4px 0;border-color:#e8ecf1;align-items:center}.cover-figure figcaption strong{font-weight:500;color:#3b4653}
.cover-figure figcaption>span:last-child{color:#8792a0;font-size:9px}
.cover-footer{border-color:#e8ecf1;font-size:10px}
@media(min-width:1500px){.cover-layout{padding:60px 0}.cover-structure{height:650px}}
@media(max-width:850px){.cover-layout{grid-template-columns:minmax(260px,.85fr) minmax(0,1.15fr)}.cover h1{font-size:64px;letter-spacing:-3.5px}.cover-description{font-size:13px}.cover-structure{height:440px}.cover-key{gap:10px;font-size:9px}.cover-figure figcaption{font-size:9px}}
@media(max-width:600px){.cover-top{padding-top:25px}.cover-wordmark{padding-top:0}.cover-top-link{font-size:10px}.cover-top-link span{margin-left:3px}.cover-layout{grid-template-columns:1fr;padding:44px 0 24px;gap:18px}.cover h1{font-size:66px;letter-spacing:-3.6px}.cover-kicker{margin-bottom:20px}.cover-description{margin-bottom:24px}.cover-key{margin-top:25px;max-width:none}.cover-structure{height:360px;max-width:none}.cover-figure figcaption{font-size:10px}.cover-footer{gap:10px}}
@media(prefers-reduced-motion:reduce){.cover-cta{transition:none}.cover-cta:hover{transform:none}}


.key-surface{background:#b7d5e9;border:1px solid #8eafc4}.cover-key i.key-confidence{width:30px;border-radius:2px;background:linear-gradient(90deg,#dea260,#d5bf4b,#72a9bc,#274a7d)}


.target-overview{margin:0 0 32px;padding:0 0 18px;border-bottom:1px solid var(--line)}
.target-overview-heading{display:flex;align-items:center;justify-content:space-between;gap:16px;margin:0 0 14px}
.target-overview-heading h2{font:600 15px Manrope,sans-serif;margin:0}
.target-overview-heading label{display:flex;align-items:center;gap:8px;font-size:12px;color:var(--muted)}
.target-overview-heading select{font:inherit;color:var(--ink);padding:6px 8px;border:1px solid var(--line);background:#fff;border-radius:4px}
.target-heatmap{display:grid;grid-template-columns:repeat(10,minmax(0,1fr));gap:2px}
.target-heatmap-cell{display:flex;align-items:center;justify-content:center;min-width:0;min-height:32px;padding:5px 2px;background:var(--cell-bg);color:var(--cell-ink);font-size:clamp(10px,1.15vw,15px);font-weight:500;text-decoration:none!important;line-height:1.2;position:relative}
.target-heatmap-cell:hover,.target-heatmap-cell:focus-visible{outline:2px solid #183f65;outline-offset:-2px;z-index:1}
.target-heatmap-cell.missing,.heatmap-legend i.missing{border:1px dashed #acb9c3;background:#fff}
.heatmap-legend{display:flex;flex-wrap:wrap;gap:12px 24px;margin-top:18px;color:#374b5c;font-size:12px}
.heatmap-legend>span{display:flex;align-items:center;gap:7px}
.heatmap-legend i{display:inline-block;width:22px;height:15px;flex-shrink:0}
.heatmap-legend small{font-size:inherit;color:var(--muted)}
.heatmap-readout{font-size:12px;line-height:1.6;min-height:20px;color:var(--muted);margin:14px 0 0}
.target-heatmap>.empty{grid-column:1/-1;margin:0}
@media(max-width:1100px){.target-heatmap-cell{font-size:11px;min-height:29px}}
@media(max-width:700px){.target-heatmap{grid-template-columns:repeat(5,minmax(0,1fr))}.target-heatmap-cell{min-height:35px;font-size:11px}.heatmap-legend{gap:10px 16px;font-size:11px}}
@media(max-width:400px){.target-heatmap{grid-template-columns:repeat(3,minmax(0,1fr))}.target-overview-heading{align-items:flex-start}.target-overview-heading label{flex-direction:column;align-items:flex-end;gap:4px}}

.heatmap-basis{font-size:11px;line-height:1.7;color:var(--muted);margin:14px 0 0;max-width:960px}.heatmap-basis a{white-space:nowrap;margin-left:8px}

#cover-canvas{cursor:grab;touch-action:none}#cover-canvas.dragging{cursor:grabbing}#cover-canvas:focus-visible{outline:2px solid var(--blue);outline-offset:3px}


.overview-view-controls{display:flex;align-items:center;gap:20px;flex-wrap:wrap}
.catalogue-view-toggle{display:flex;border:1px solid var(--line);border-radius:6px;padding:3px;gap:3px}
.catalogue-view-toggle button{border:0;border-radius:3px;padding:7px 12px;background:transparent;color:var(--muted);font-size:12px;min-height:34px}
.catalogue-view-toggle button[aria-pressed="true"]{background:#eaf1f9;color:#245894}
.catalogue-view-toggle button:hover{background:#f1f5f9}
.catalogue .target-list{display:block;overflow-x:auto;height:auto}
.target-table{width:100%;border-collapse:collapse;font-size:13px;line-height:1.5}
.target-table th,.target-table td{padding:14px 12px;border-bottom:1px solid var(--line);text-align:left;vertical-align:top}
.target-table thead th{font-size:11px;color:var(--muted);font-weight:500;white-space:nowrap}

.target-table .table-sort{font:inherit;color:inherit;border:0;background:none;padding:6px 0;margin:-6px 0;cursor:pointer;white-space:nowrap}
.target-table .table-sort span{display:inline-block;min-width:1em;margin-left:3px;color:var(--blue)}
.target-table .table-sort:hover,.target-table th[aria-sort="ascending"] .table-sort,.target-table th[aria-sort="descending"] .table-sort{color:var(--blue)}
.target-table .table-sort:focus-visible{outline:2px solid var(--blue);outline-offset:4px;border-radius:2px}
.target-table tbody th{font-weight:600;white-space:nowrap}
.target-table td:nth-last-child(-n+4),.target-table thead th:nth-last-child(-n+4){text-align:right;font-variant-numeric:tabular-nums;white-space:nowrap}
.target-table tbody tr:hover{background:#f6f9fc}
.target-table-name{max-width:450px}
#target-list[hidden],#target-heatmap[hidden],#heatmap-legend[hidden],#heatmap-metric-label[hidden]{display:none}
#sequence-disclosure>summary{cursor:pointer;font-size:14px;font-weight:600;padding:4px 0;min-height:28px}
#sequence-disclosure>summary span{font-size:11px;color:var(--muted);font-weight:400;margin-left:14px}
#sequence-disclosure[open]>summary{margin-bottom:18px}
@media(max-width:600px){nav a{font-size:12px;min-height:44px;display:flex;align-items:center}.target-overview-heading{flex-wrap:wrap;gap:12px}.overview-view-controls{width:100%;justify-content:space-between;gap:8px}.target-table{font-size:12px}.target-table th,.target-table td{padding:12px 8px}.target-table .target-table-name,.target-table thead th:nth-child(2){display:none}}

.release-terms{padding:20px 24px;text-align:center;font-size:13px;color:#555}.release-terms a{color:#2E6FBA}.download-terms{font-size:12px;line-height:1.6}

.home-page{background:#fff;min-height:100vh}